Letter: Hyoscine butylbromide and the oculo-cardiac reflex.

oculo-cardiac reflex during strabismus surgery

purpose: to evaluate the incidence of the oculo-cardiac reflex (ocr) and its associated risk factors during strabismus surgeries performed at a tertiary referral center between 1390 and 1392. methods: over a 2-year period, all strabismus surgery candidates were enrolled in the study after obtaining consent from the patients or their parents. vital signs were recorded before the initiation of th...

Studies on the development of rapidly disintegrating hyoscine butylbromide tablets.

The objective of this study was to prepare hyoscine butylbromide (a drug with bitter taste) tablets that can rapidly disintegrate in saliva. The granules were prepared by the extrusion method using aminoalkyl methacrylate copolymers (Eudragit E-100). The drugs dissolved rapidly in medium at pH 1.2 in a dissolution test while none of the drugs dissolved from the granules (% of dissolved < 5%) ev...

pharmacotherapy Update: Hyoscine Butylbromide in the Treatment of Abdominal spasms

Abdominal pain is one of the most common reasons why people seek medical care, and is often due to spasm of intra-abdominal visceral organs. Hyoscine butylbromide (HBB) is a quaternary ammonium compound which blocks the action of acetylcholine at parasympathetic sites (both muscarinic and nicotinic receptors) in smooth muscle, and in secretory glands. It causes decreased motility of the gastroi...

Angioneurotic oedema and urticaria induced by hyoscine butylbromide.

Case report A 23-year-old white female was admitted to hospital following the sudden onset of swelling of her eyelids, urticarial lesions on her trunk and extremities and a feeling of tightness in her throat. The patient was being treated symptomatically for abdominal colic with hyoscine butylbromide (Buscopan) 10 mg three times a day and had taken one week's supply before the onset of her symp...

Effect of hyoscine butylbromide on cervical dilation during labor